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prmt4 inhibitor tp 064  (Tocris)


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    Tocris prmt4 inhibitor tp 064
    FIGURE 1 Aged female 3xTg‐AD mice exhibit differential expression of <t>PRMT4</t> which can be reversed by TP‐064. Relative mRNA levels and protein of PRMTs in the cortex and hippocampus were measured by quantitative RT‐PCR and capillary‐based immunoassay, respectively. (a) Relative mRNA levels of PRMTs 1−9 were measured in brain tissue from aged, female C57 and 3xTg mice. (b, c) Relative protein expression of protein arginine methyltransferase 6 (PRMT6) (~45 kDA) (b) and PRMT4 (~63 kDA) (c) were measured via ProteinSimple capillary‐based immunoassay in cortical and hippocampal lysates from aged, female C57 and 3xTg animals. (d) Computer generated pseudo‐blot images depcting representative bands for PRMT4 and PRMT6. (e) PRMT4 inhibitorTP‐064 reduced PRMT4 protein expression in a dose‐dependent manner. Results are expressed as mean ± SEM, n indicates number of animals used. *p < 0.05, **p < 0.02, ***p < 0.01, v. control or untreated 3xTg, evaluated by one‐way ANOVA with Bonferroni (1a)/Tukey's (1e) post‐hoc analysis respectively and Student's t‐test as appropriate, (n = 3−6). PRMT4, protein arginine methyltransferase 4.
    Prmt4 Inhibitor Tp 064, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/prmt4+inhibitor+tp+064/pm36036549-51-4-10?v=Tocris
    Average 93 stars, based on 13 article reviews
    prmt4 inhibitor tp 064 - by Bioz Stars, 2026-07
    93/100 stars

    Images

    1) Product Images from "Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease."

    Article Title: Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease.

    Journal: Journal of cellular physiology

    doi: 10.1002/jcp.30858

    FIGURE 1 Aged female 3xTg‐AD mice exhibit differential expression of PRMT4 which can be reversed by TP‐064. Relative mRNA levels and protein of PRMTs in the cortex and hippocampus were measured by quantitative RT‐PCR and capillary‐based immunoassay, respectively. (a) Relative mRNA levels of PRMTs 1−9 were measured in brain tissue from aged, female C57 and 3xTg mice. (b, c) Relative protein expression of protein arginine methyltransferase 6 (PRMT6) (~45 kDA) (b) and PRMT4 (~63 kDA) (c) were measured via ProteinSimple capillary‐based immunoassay in cortical and hippocampal lysates from aged, female C57 and 3xTg animals. (d) Computer generated pseudo‐blot images depcting representative bands for PRMT4 and PRMT6. (e) PRMT4 inhibitorTP‐064 reduced PRMT4 protein expression in a dose‐dependent manner. Results are expressed as mean ± SEM, n indicates number of animals used. *p < 0.05, **p < 0.02, ***p < 0.01, v. control or untreated 3xTg, evaluated by one‐way ANOVA with Bonferroni (1a)/Tukey's (1e) post‐hoc analysis respectively and Student's t‐test as appropriate, (n = 3−6). PRMT4, protein arginine methyltransferase 4.
    Figure Legend Snippet: FIGURE 1 Aged female 3xTg‐AD mice exhibit differential expression of PRMT4 which can be reversed by TP‐064. Relative mRNA levels and protein of PRMTs in the cortex and hippocampus were measured by quantitative RT‐PCR and capillary‐based immunoassay, respectively. (a) Relative mRNA levels of PRMTs 1−9 were measured in brain tissue from aged, female C57 and 3xTg mice. (b, c) Relative protein expression of protein arginine methyltransferase 6 (PRMT6) (~45 kDA) (b) and PRMT4 (~63 kDA) (c) were measured via ProteinSimple capillary‐based immunoassay in cortical and hippocampal lysates from aged, female C57 and 3xTg animals. (d) Computer generated pseudo‐blot images depcting representative bands for PRMT4 and PRMT6. (e) PRMT4 inhibitorTP‐064 reduced PRMT4 protein expression in a dose‐dependent manner. Results are expressed as mean ± SEM, n indicates number of animals used. *p < 0.05, **p < 0.02, ***p < 0.01, v. control or untreated 3xTg, evaluated by one‐way ANOVA with Bonferroni (1a)/Tukey's (1e) post‐hoc analysis respectively and Student's t‐test as appropriate, (n = 3−6). PRMT4, protein arginine methyltransferase 4.

    Techniques Used: Quantitative Proteomics, Quantitative RT-PCR, Expressing, Generated, Control

    FIGURE 5 PRMT4 inhibition via TP‐064 enhances regional cortical cerebral blood flow. Representative flux image of cortical vasculature via laser speckle contrast imaging (a). Aged 3xTg‐AD female mice had impaired cortical regional cerebral blood flow as compared to age/sex‐ matched control C57 mice, while treatment with TP‐064 (30 mg/kg, 7 days, IP) enhanced cerebral blood flow (b). Results are expressed as mean ± SEM, n indicates number of animals used, *p < 0.05 v. C57, #p < 0.05 v. 3xTg and C57 ± TP‐064 evaluated by two‐way ANOVA with Tukey's post hoc analyses. PRMT4, protein arginine methyltransferase 4.
    Figure Legend Snippet: FIGURE 5 PRMT4 inhibition via TP‐064 enhances regional cortical cerebral blood flow. Representative flux image of cortical vasculature via laser speckle contrast imaging (a). Aged 3xTg‐AD female mice had impaired cortical regional cerebral blood flow as compared to age/sex‐ matched control C57 mice, while treatment with TP‐064 (30 mg/kg, 7 days, IP) enhanced cerebral blood flow (b). Results are expressed as mean ± SEM, n indicates number of animals used, *p < 0.05 v. C57, #p < 0.05 v. 3xTg and C57 ± TP‐064 evaluated by two‐way ANOVA with Tukey's post hoc analyses. PRMT4, protein arginine methyltransferase 4.

    Techniques Used: Inhibition, Imaging, Control



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    FIGURE 1 Aged female 3xTg‐AD mice exhibit differential expression of <t>PRMT4</t> which can be reversed by TP‐064. Relative mRNA levels and protein of PRMTs in the cortex and hippocampus were measured by quantitative RT‐PCR and capillary‐based immunoassay, respectively. (a) Relative mRNA levels of PRMTs 1−9 were measured in brain tissue from aged, female C57 and 3xTg mice. (b, c) Relative protein expression of protein arginine methyltransferase 6 (PRMT6) (~45 kDA) (b) and PRMT4 (~63 kDA) (c) were measured via ProteinSimple capillary‐based immunoassay in cortical and hippocampal lysates from aged, female C57 and 3xTg animals. (d) Computer generated pseudo‐blot images depcting representative bands for PRMT4 and PRMT6. (e) PRMT4 inhibitorTP‐064 reduced PRMT4 protein expression in a dose‐dependent manner. Results are expressed as mean ± SEM, n indicates number of animals used. *p < 0.05, **p < 0.02, ***p < 0.01, v. control or untreated 3xTg, evaluated by one‐way ANOVA with Bonferroni (1a)/Tukey's (1e) post‐hoc analysis respectively and Student's t‐test as appropriate, (n = 3−6). PRMT4, protein arginine methyltransferase 4.
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    FIGURE 1 Aged female 3xTg‐AD mice exhibit differential expression of <t>PRMT4</t> which can be reversed by TP‐064. Relative mRNA levels and protein of PRMTs in the cortex and hippocampus were measured by quantitative RT‐PCR and capillary‐based immunoassay, respectively. (a) Relative mRNA levels of PRMTs 1−9 were measured in brain tissue from aged, female C57 and 3xTg mice. (b, c) Relative protein expression of protein arginine methyltransferase 6 (PRMT6) (~45 kDA) (b) and PRMT4 (~63 kDA) (c) were measured via ProteinSimple capillary‐based immunoassay in cortical and hippocampal lysates from aged, female C57 and 3xTg animals. (d) Computer generated pseudo‐blot images depcting representative bands for PRMT4 and PRMT6. (e) PRMT4 inhibitorTP‐064 reduced PRMT4 protein expression in a dose‐dependent manner. Results are expressed as mean ± SEM, n indicates number of animals used. *p < 0.05, **p < 0.02, ***p < 0.01, v. control or untreated 3xTg, evaluated by one‐way ANOVA with Bonferroni (1a)/Tukey's (1e) post‐hoc analysis respectively and Student's t‐test as appropriate, (n = 3−6). PRMT4, protein arginine methyltransferase 4.
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    Image Search Results


    FIGURE 1 Aged female 3xTg‐AD mice exhibit differential expression of PRMT4 which can be reversed by TP‐064. Relative mRNA levels and protein of PRMTs in the cortex and hippocampus were measured by quantitative RT‐PCR and capillary‐based immunoassay, respectively. (a) Relative mRNA levels of PRMTs 1−9 were measured in brain tissue from aged, female C57 and 3xTg mice. (b, c) Relative protein expression of protein arginine methyltransferase 6 (PRMT6) (~45 kDA) (b) and PRMT4 (~63 kDA) (c) were measured via ProteinSimple capillary‐based immunoassay in cortical and hippocampal lysates from aged, female C57 and 3xTg animals. (d) Computer generated pseudo‐blot images depcting representative bands for PRMT4 and PRMT6. (e) PRMT4 inhibitorTP‐064 reduced PRMT4 protein expression in a dose‐dependent manner. Results are expressed as mean ± SEM, n indicates number of animals used. *p < 0.05, **p < 0.02, ***p < 0.01, v. control or untreated 3xTg, evaluated by one‐way ANOVA with Bonferroni (1a)/Tukey's (1e) post‐hoc analysis respectively and Student's t‐test as appropriate, (n = 3−6). PRMT4, protein arginine methyltransferase 4.

    Journal: Journal of cellular physiology

    Article Title: Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease.

    doi: 10.1002/jcp.30858

    Figure Lengend Snippet: FIGURE 1 Aged female 3xTg‐AD mice exhibit differential expression of PRMT4 which can be reversed by TP‐064. Relative mRNA levels and protein of PRMTs in the cortex and hippocampus were measured by quantitative RT‐PCR and capillary‐based immunoassay, respectively. (a) Relative mRNA levels of PRMTs 1−9 were measured in brain tissue from aged, female C57 and 3xTg mice. (b, c) Relative protein expression of protein arginine methyltransferase 6 (PRMT6) (~45 kDA) (b) and PRMT4 (~63 kDA) (c) were measured via ProteinSimple capillary‐based immunoassay in cortical and hippocampal lysates from aged, female C57 and 3xTg animals. (d) Computer generated pseudo‐blot images depcting representative bands for PRMT4 and PRMT6. (e) PRMT4 inhibitorTP‐064 reduced PRMT4 protein expression in a dose‐dependent manner. Results are expressed as mean ± SEM, n indicates number of animals used. *p < 0.05, **p < 0.02, ***p < 0.01, v. control or untreated 3xTg, evaluated by one‐way ANOVA with Bonferroni (1a)/Tukey's (1e) post‐hoc analysis respectively and Student's t‐test as appropriate, (n = 3−6). PRMT4, protein arginine methyltransferase 4.

    Article Snippet: Treatment consisted of specific PRMT4 inhibitor TP‐064 (Cat. No. 6008; Tocris) (Zhang et al., 2021; Zhong et al., 2018).

    Techniques: Quantitative Proteomics, Quantitative RT-PCR, Expressing, Generated, Control

    FIGURE 5 PRMT4 inhibition via TP‐064 enhances regional cortical cerebral blood flow. Representative flux image of cortical vasculature via laser speckle contrast imaging (a). Aged 3xTg‐AD female mice had impaired cortical regional cerebral blood flow as compared to age/sex‐ matched control C57 mice, while treatment with TP‐064 (30 mg/kg, 7 days, IP) enhanced cerebral blood flow (b). Results are expressed as mean ± SEM, n indicates number of animals used, *p < 0.05 v. C57, #p < 0.05 v. 3xTg and C57 ± TP‐064 evaluated by two‐way ANOVA with Tukey's post hoc analyses. PRMT4, protein arginine methyltransferase 4.

    Journal: Journal of cellular physiology

    Article Title: Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease.

    doi: 10.1002/jcp.30858

    Figure Lengend Snippet: FIGURE 5 PRMT4 inhibition via TP‐064 enhances regional cortical cerebral blood flow. Representative flux image of cortical vasculature via laser speckle contrast imaging (a). Aged 3xTg‐AD female mice had impaired cortical regional cerebral blood flow as compared to age/sex‐ matched control C57 mice, while treatment with TP‐064 (30 mg/kg, 7 days, IP) enhanced cerebral blood flow (b). Results are expressed as mean ± SEM, n indicates number of animals used, *p < 0.05 v. C57, #p < 0.05 v. 3xTg and C57 ± TP‐064 evaluated by two‐way ANOVA with Tukey's post hoc analyses. PRMT4, protein arginine methyltransferase 4.

    Article Snippet: Treatment consisted of specific PRMT4 inhibitor TP‐064 (Cat. No. 6008; Tocris) (Zhang et al., 2021; Zhong et al., 2018).

    Techniques: Inhibition, Imaging, Control